Vegetation and fauna
The Salmon-crested Cockatoo is a threatened species which has a stronghold in the national park

Among the plants that grow in this park are Avicennia, Dryobalanops and Pandanus species, Alstonia scholaris, Terminalia catappa, Shorea selanica, Octomeles sumatrana, Bruguiera sexangula, Melaleuca leucadendra, Pometia pinnata, Rhizophora acuminata and various species of orchid.

Of the 117 species of bird on the island, 14 are endemic, including the Eclectus Parrot, Purple-naped Lory, Salmon-crested Cockatoo, Lazuli Kingfisher, Sacred Kingfisher, Grey-necked Friarbird, Moluccan King Parrot,Bicoloured White-eye and Black-chinned Monarch.

The mammals found on Seram include Asian species (murid rodents) as well as Australasian marsupials. The montane area of Seram supports the greatest number of endemic mammals of any island in the region. It harbors 38 mammal species and includes nine species that are endemic or near endemic, several of which are limited to montane habitats. These include the Seram Bandicoot, Moluccan Flying Fox, Seram Flying-fox, Manusela Mosaic-tailed Rat, Spiny Ceram Rat and the Ceram Rat, all considered threatened.

Human habitation
There are four villages in the park: Manusela, Ilena Maraina, Selumena and Kanike. Manusela is also the name of one of the mountains within the park, the local ethnic group and their language. In the local language Manusela means “bird of freedom”.

Conservation and threats
In 1972 two areas in central Seram were designated as nature reserves: Wae Nua (20,000 ha) and Wae Mual (17,500 ha). After a survey in 1978 a proposal was made to unite the two areas to form Manusela National Park.Manusela National Park was established in 1997, to protect an area of 1,890 km², representing 11% of the land area of Seram island.

A major threat is posed by deforestation, with logging concessions covering 48% of Seram’s forest, and illegal logging even having been recorded inside Manusela National Park.Another threat is posed by illegal wild bird trading, particularly targeting the Salmon-crested Cockatoo. The population of the endemic Salmon-crested Cockatoo is now gravely threatened due to hunting and the destruction of its habitat,and the park remains its last stronghold. For the first time in 2006 nine cockatoos have been released in the wild after being confiscated from a smuggler in 2004.